Research of target molecule of eosinophilic rhinosinusitis by pharmacogenomics of steroids

类固醇药物基因组学研究嗜酸性鼻窦炎靶分子

• 批准号: 22791633
• 负责人: KAWANO Kenji
• 金额: $ 2.5万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791633/
• 关键词: 慢性副鼻腔炎治療; 好酸球性副鼻腔炎; マクロライド; ステロイド; 競合ハイブリダイゼーション

Chronic rhinosinusitis(CRS) with eosinophilic infiltration is a type of intractable rhinosinusitis often associated with asthma. Heme oxygenase-1(HO-1), a cytoprotective enzyme against oxidant, has been extensively studied in airway diseases. We found that the expression of HO-1 in the epithelial layers of CRS without eosinophilic infiltration was significantly enhanced as compared with that of CRS with eosinophilic infiltration. On the other hand, the number of macrophages with HO-1 positive reactions was significantly greater in CRS with eosinophilic infiltration compared with CRS without eosinophilic infiltration. O

慢性鼻窦炎伴嗜酸性粒细胞浸润是一种难治性鼻窦炎，常伴发哮喘。血红素氧合酶-1（HO-1）是一种抗氧化的细胞保护酶，在气道疾病中已被广泛研究。我们发现，与有嗜酸性粒细胞浸润的CRS相比，无嗜酸性粒细胞浸润的CRS上皮层中HO-1的表达显著增强。另一方面，与无嗜酸性粒细胞浸润的CRS相比，有嗜酸性粒细胞浸润的CRS中具有HO-1阳性反应的巨噬细胞的数量显著增加。O

项目成果

Heme oxygenase-1 expression in chronic rhinosinusitis with eosinophilic infiltration

• DOI: 10.1016/j.anl.2011.10.001
• 发表时间: 2012-08-01
• 期刊: AURIS NASUS LARYNX
• 影响因子: 1.7
• 作者: Kawano, Kenji;Kusunoki, Takeshi;Ikeda, Katsuhisa
• 通讯作者: Ikeda, Katsuhisa

A randomized prospective study of oral levofloxacin vs intravenous flomoxef prophylaxis in postoperative infection after endoscopic sinus surgery

口服左氧氟沙星与静脉注射氟氧头孢预防内窥镜鼻窦手术后感染的随机前瞻性研究

• 发表时间: 2009
• 期刊: Am J Otolaryngol
• 作者: Inoshita A;Yokoi H;Matsumoto F;Yao T;Kawano K;Furukawa M;Ikeda K.
• 通讯作者: Ikeda K.