Mechanisms of cancer-induced pain in orofacial cancer model of rats

由于口面部癌症引起的疼痛导致进食困难，口面部癌症患者的症状可能比其他地区的癌症患者更严重。在本研究中，我们研究了癌性疼痛的机制在大鼠面部癌症模型。因此，我们已经证明癌症引起的疼痛是由中央胶质细胞过度激活引起的，独立于炎症和神经损伤。提示抗胶质细胞活化药物可能在临床上用于抑制癌性疼痛。

Since orofacial cancer-induced pain causes difficulties in eating, the symptoms of patients with orofacial cancer may be more severe than those of patients with cancer in other regions. In the present study, we investigated mechanism of cancer-induced pain in a rat facial cancer model. Consequently, we have demonstrated that cancer-induced pain is caused by central glial hyper-activation, independently on inflammation and nerve injury. The result suggests that anti-glial activation drugs may be available to inhibit cancer-induced pain in clinical side.