Functions of Cdc42 during skeletal development
Functions of Cdc42 during skeletal development
批准号:
22791798
负责人:
YAMADA Atsushi
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Cdc42, a member of the Rho subfamily of small GTPases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis. To investigate the physiological function of Cdc42 during limb development, we generated limb bud mesenchyme-specific inactivated Cdc42(Cdc42^<fl/fl>; Prx1-Cre) mice. Cdc42^<fl/fl>; Prx1-Cre mice demonstrated short limbs and body, abnormal calcification of the cranium, cleft palate, disruption of the xiphoid process, and syndactyly. Syndactyly in Cdc42^<fl/fl>; Prx1-Cre mice was caused by fusion of metacarpals and a failure of interdigital programmed cell death(ID-PCD). These results demonstrate that Cdc42 is essential for chondrogenesis and ID-PCD during limb development.
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DOI:
10.1074/jbc.m111.221259
发表时间:
2011-03
期刊:
The Journal of Biological Chemistry
影响因子:
--
作者:
[K. Yoshimura;Y. Miyamoto;R. Yasuhara;Toshifumi Maruyama;T. Akiyama;A. Yamada;M. Takami;T. Suzawa;Shoko Tsunawaki;T. Tachikawa;Kazuyoshi Baba;R. Kamijo]
通讯作者:
K. Yoshimura;Y. Miyamoto;R. Yasuhara;Toshifumi Maruyama;T. Akiyama;A. Yamada;M. Takami;T. Suzawa;Shoko Tsunawaki;T. Tachikawa;Kazuyoshi Baba;R. Kamijo
Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-alpha
POEM(成骨细胞分化的正调节因子)的表达被 TNF-α 抑制
DOI:
--
发表时间:
2011
期刊:
Biochem.Biophys.Res.Cmmun.
影响因子:
--
作者:
[Tsukasaki M., et al]
通讯作者:
et al
Alx3はBMP-2による骨芽細胞分化を制御する
Alx3 通过 BMP-2 控制成骨细胞分化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[松本貴志, 山田篤, 鈴木大, 馬場一美, 上條竜太郎]
通讯作者:
上條竜太郎
ホメオボックス遺伝子Alx3はBMP-2による骨芽細胞分化を制御する
同源盒基因 Alx3 通过 BMP-2 控制成骨细胞分化
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[柴田陽, 鈴木大, 大森さゆり, 田中玲奈, 村上明日香, 片岡有, 馬場一美, 上條竜太郎, 宮崎隆, Matsumoto T, 鈴木大, 松本貴志]
通讯作者:
松本貴志
TNF-alphaはPOEMの発現を抑制し、骨芽細胞分化を制御する.
TNF-α 抑制 POEM 表达并控制成骨细胞分化。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakayama K, Ihara Y, Inoue T, 塚崎雅之,他]
通讯作者:
塚崎雅之,他
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