Effects of angiogenesis inhibitor and fibroblast growth inhibitor on invasion and metastasis of oral squamous cell carcinoma.

采用可复制口腔癌侵袭转移的原位植入小鼠模型，研究了抗癌剂和成纤维细胞生长抑制剂对口腔癌侵袭转移的抑制作用。将一株高度侵袭性转移性人口腔鳞状细胞癌细胞OLC-01植入裸鼠舌内，植入后给予小鼠顺铂或曲尼司特。观察各药物对肿瘤侵袭转移的影响。顺铂和曲尼司特联合组肿瘤大小和间质胶原纤维体积均明显减小。联合组肿瘤间质性质发生改变。考虑到这些作用，使用抗癌药物和成纤维细胞生长抑制剂在临床上可能是非常有用的。

Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and fibroblast growth inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OLC-01, was implanted into the tongue of nude mice, and cisplatin or tranilast were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasis were investigated. Tumor sizes and stromal collagen fiber volumes were significantly reduced in conbination group of cisplatin and tranilast. And tumor stromas were changed properties in conbination group. The use of anticancer agent and fibroblast growth inhibitor considering these effects may be clinically very useful.