Effects of angiogenesis inhibitor and fibroblast growth inhibitor on invasion and metastasis of oral squamous cell carcinoma.

本研究采用原位种植的小鼠口腔癌模型，研究了抗癌药物和成纤维细胞生长抑制剂对口腔癌侵袭和转移的抑制作用。将高度侵袭和转移的人口腔鳞状细胞癌细胞系OLC-01植入裸鼠舌中，并在植入后向小鼠施用顺铂或曲尼司特。研究了每种药物对肿瘤侵袭和转移的影响。曲尼司特联合顺铂组肿瘤体积和间质胶原纤维体积明显缩小。联合组肿瘤间质性质改变。考虑到这些作用，使用抗癌剂和成纤维细胞生长抑制剂可能在临床上非常有用。

Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and fibroblast growth inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OLC-01, was implanted into the tongue of nude mice, and cisplatin or tranilast were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasis were investigated. Tumor sizes and stromal collagen fiber volumes were significantly reduced in conbination group of cisplatin and tranilast. And tumor stromas were changed properties in conbination group. The use of anticancer agent and fibroblast growth inhibitor considering these effects may be clinically very useful.