Effects of angiogenesis inhibitor and fibroblast growth inhibitor on invasion and metastasis of oral squamous cell carcinoma.

采用可复制口腔癌侵袭转移的小鼠原位移植模型，研究了抗癌药物、成纤维细胞生长抑制因子和抗血管生成药物对口腔癌侵袭转移的抑制作用。将高侵袭性、高转移性的口腔鳞状细胞癌细胞系OLC-01、OSC-19接种于裸小鼠舌内，移植后给予顺铂、曲尼司特或阿瓦斯丁。观察每种药物对肿瘤侵袭转移的影响。顺铂联合曲尼司特治疗组肿瘤体积和间质胶原纤维含量明显减少。联合组肿瘤间质有特征性改变。阿瓦斯丁组的淋巴结转移和血管生成明显减少，考虑到这些影响的抗癌药物、成纤维细胞生长抑制因子和抗血管生成药物的使用可能在临床上非常有用。

Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and fibroblast growth inhibitor and antiangiogenic agent on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OLC-01, OSC-19 was implanted into the tongue of nude mice, and cisplatin or tranilast or avastin were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasis were investigated. Tumor size and stroma collagen fiber content were significantly reduced in conbination group of cisplatin and tranilast. And tumor stroma were changed charactaristic in conbination group. Lymph node matastasis and vascularization were significantly reduced in avastin group.The use of anticancer agent and fibroblast growth inhibitor and antiangiogenic agent considering these effects may be clinically very useful.