Analysis of stem/progenitor cell in human irradiated salivarygland

人类辐照唾液腺干/祖细胞分析

• 批准号: 22791999
• 负责人: SATO Yuki
• 金额: $ 1.83万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791999/
• 关键词: 唾液腺; 放射線; 幹細胞; アミラーゼ

The salivary gland stem/progenitor cells were examined using the irradiated human salivary gland cells and human salivary-glands cancer cell line. In the irradiated-salivary gland tissue, salivary gland stem cell was not isolated stably. Sarivary gland cancer cell line showed proliferation with re-multidifferentiation. Furthermore, the salivary-glands amylase activity at the time of invasion was measured immunohistologically, salivary-glands amylase activity went up at the time of invasion, indicating that amylase activity was involving closely the activity dynamic state of a salivary-glands stem/progenitor cell.

用照射的人涎腺细胞和人涎腺癌细胞系检测涎腺干/祖细胞。在照射后的涎腺组织中，涎腺干细胞分离不稳定。涎腺癌细胞系呈增殖和再分化。免疫组织化学方法检测侵袭时唾液腺淀粉酶活性，发现侵袭时唾液腺淀粉酶活性升高，说明淀粉酶活性与唾液腺干/祖细胞的活性动态密切相关。

项目成果

唾液アミラーゼを用いたストレス評価の検討

唾液淀粉酶应激评价研究

• 发表时间: 2010
• 作者: 佐藤有紀;廣田誠;藤内祝
• 通讯作者: 藤内祝

唾液腺アミラーゼを用いたストレス評価の検討

使用唾液腺淀粉酶进行压力评估检查

• 发表时间: 2010
• 作者: 佐藤有紀;廣田誠;藤内祝
• 通讯作者: 藤内祝