Dose cyclosporine induce hyperalgesia? : The effect of cyclosporine on pain reaction

点击翻译按钮获取中文摘要

In the setting of organ and stem-cell transplantation, calcineurin-inhibitor-induced pain syndrome (CIPS) has recently been recognized. In our study, we found that cyclosporine increases pain reaction, increases anxiety-related behavior, and disturbed social behavior by reducing the release of serotoin and dopamine in mice. In order to support these evidences in human, we have also examined the thermal noxious stimulation based on heat flux using the perfusion index and found that it could be a useful tool to evaluate pain reaction in clinical situation.