The involvement of adenosine and nitric oxide in cardioprotective effects of volatile anesthetics on ischemic myocardium

急性暴露于七氟醚和一氧化氮供体对慢性双嘧达莫诱导的缺血再灌注损伤预适应具有附加的心脏保护作用。七氟醚、一氧化氮供体和双嘧达莫联合药物预处理可能是围手术期增强心脏保护的有效策略。双嘧达莫诱导的心脏预适应在停药后持续3天，并通过Akt和eNOS激活介导。

Acute exposure to sevoflurane and NO donor produced additive cardioprotection to chronic dipyridamole-induced preconditioning against ischemia-reperfusion injury. Combined pharmaceutical preconditioning with sevoflurane, NO donor and dipyridamole may prove an effective strategy to enhance cardioprotection in the perioperative setting.Dipyridamole-induced cardiac preconditioning persists for 3 days after discontinuing therapy and is mediated through Akt and eNOS activation.