The involvement of adenosine and nitric oxide in cardioprotective effects of volatile anesthetics on ischemic myocardium

急性暴露于七氟醚和NO供体对慢性潘生丁诱导的预处理抗缺血再灌注损伤产生额外的心脏保护作用。联合七氟醚、NO供体和潘生丁的药物预处理可能被证明是一种有效的策略，以增强围手术期的心脏保护作用。潘生丁诱导的心脏预处理在停止治疗后持续3天，并通过Akt和eNOS激活介导。

Acute exposure to sevoflurane and NO donor produced additive cardioprotection to chronic dipyridamole-induced preconditioning against ischemia-reperfusion injury. Combined pharmaceutical preconditioning with sevoflurane, NO donor and dipyridamole may prove an effective strategy to enhance cardioprotection in the perioperative setting.Dipyridamole-induced cardiac preconditioning persists for 3 days after discontinuing therapy and is mediated through Akt and eNOS activation.