The role for the stress protein in regulation of development of themandibular condylar cartilage by mechanical stress

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This study investigated the localization and expression of heme oxygenase (HO)-1, type II and X collagen (Col10 and 2) and matrix metalloproteinase (MMP)-13 proteins in mouse mandibular condylar cartilage and mouse tibial cartilage. C57BL/6J mice aged 1, 7, 14, 21 and 49 days were subjected to using immunohistochemistry. This study demonstrated that HO-1 is the protein which expresses specifically to early stages of the development, in particular under hypoxia environment in chondrocytes. These findings suggest that HO-1 is involved in the process of the endochondral ossification from a blood vessel invasion in hypertrophic chondrocytes and acts as a regulatory factor in the early stages of the development of condylar cartilage.