Development of the catalyst featured by chemicallyπ-space for asymmetric Suzuki-Miyaura reaction

在本研究中，进行了一种催化剂的开发，促进不对称铃木-宫浦交叉偶联反应中的反应时间和催化剂周转。成功合成了一类新型的含手性BINOL基团的六芳基苯亚膦酸酯配体，其中一种在TON 750中实现了2-氯-3-甲氧基苯甲醛与邻甲苯基硼酸的偶联反应，反应时间为4 h，ee值分别为75%和76%。

Development of a catalyst that promotes reaction time and catalyst turnover in asymmetric Suzuki-Miyaura cross-coupling reactions was conducted in this research. The novel hexaarylbenzene-based phosphonite ligands which have chiral BINOL moieties were successfully synthesized : one of them has achieved to cross-couple 2-chlro-3-methoxybenzaldehyde with ortho-tolylboronic acid in TON 750 for 4 h, giving 75% and 76% ee. On the other hand, the elaboration was found in the reactions of sterically hindered substrates and the further development of phosphonite ligands.