Development of the catalyst featured by chemicallyπ-space for asymmetric Suzuki-Miyaura reaction

在不对称Suzuki-Miyaura交叉偶联反应中，开发了一种促进反应时间和催化剂周转的催化剂。成功合成了具有手性二酚基团的新型六芳基苯基膦酸配体，其中一种配体与邻苯三甲酸在TON 750中交叉偶联4 h， ee分别为75%和76%。另一方面，在位阻底物的反应和膦酸盐配体的进一步发展中发现了这种细化。

Development of a catalyst that promotes reaction time and catalyst turnover in asymmetric Suzuki-Miyaura cross-coupling reactions was conducted in this research. The novel hexaarylbenzene-based phosphonite ligands which have chiral BINOL moieties were successfully synthesized : one of them has achieved to cross-couple 2-chlro-3-methoxybenzaldehyde with ortho-tolylboronic acid in TON 750 for 4 h, giving 75% and 76% ee. On the other hand, the elaboration was found in the reactions of sterically hindered substrates and the further development of phosphonite ligands.