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Structural analysis of Plasmodium falciparummalaria vaccine candidate antigen SERA5

Structural analysis of Plasmodium falciparummalaria vaccine candidate antigen SERA5
恶性疟原虫疫苗候选抗原SERA5的结构分析
批准号:
22770151
负责人:
YAGI Masanori
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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英文摘要
Phase Ib clinical trial of malaria vaccine candidate SE36 in Uganda showed the safety of SE36 and possible protective effect against symptomatic malaria. However, no information has been reported on tertiary structure and physicochemical properties of SE36. This study revealed that the protective epitopes of SE36 have the characteristics of intrinsically unstructured regions and succeeded in construction of SE36 mutants suitable for structural analysis of SE36 antigen.
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