The molecular mechanism of the endogenous siRNA biogenesis

小rna对抑制mRNA转录或翻译或催化mRNA破坏的蛋白质效应复合物具有特异性。在本研究项目中，我们试图更好地了解内源性siRNA（esiRNA）生物发生的分子机制。利用果蝇细胞，我们发现了一种含有esiRNA生物发生蛋白的新型细胞质颗粒，该颗粒是esiRNA与效应复合物特异性结合所必需的。

Small RNAs provide specificity to protein effector complexes that repress mRNA transcription or translation, or catalyze mRNA destruction. In this research program, we tried to gain a better under standing of the molecular mechanisms underlying the endogenous siRNA(esiRNA) biogenesis. Using Drosophila cell, we found a novel cytoplasmic granules which contains the esiRNA biogenesis proteins and that this granule is necessary for the specific association between esiRNA and the effector complex.