Identification and analysis of biological systems required for efficient glucose consumption

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Efficient utilization of glucose is vital for a variety of physiological activities in eukaryotes. Our study using fission yeast reveals that two protein kinases, CaMKK and TORC2, are required for efficient utilization of low glucose concentrations, which are equivalent to a human blood glucose level. CaMKK is found to be involved in regulation of abundance of hexose transporter proteins, full function of which is essential for incorporation of low glucose concentrations, while TORC2 is involved in proper targeting of the transporters on the cell surface. These results may provide new insight into the cellular mechanism maintaining the blood glucose level.