Wnt-dependent regulation of neuro-mesodermal precursor cells

脊椎动物通过增加后部组织而发育。众所周知，Wnt信号在这一过程中起着重要作用。然而，Wnt在这一过程中的作用机制尚不清楚。我发现在原始条纹区有一个共同的前体细胞衍生神经细胞和中胚层细胞。SOX2和TBX6两个转录因子分别控制神经原始细胞和中胚层细胞的命运。这些基因的表达受Wnt信号调控。

Vertebrate develops by addition of posterior tissues. It is well known that Wnt signal has an important role in this process. However, the mechanism of Wnt action in this process remains unknown.I found that there is a common precursor cell deriving neural and mesodermal cell in the primitive streak region. Two transcription factors, SOX2 and TBX6, control the fate toward neural primordial cells and mesodermal cells, respectively. The expression of these genes is regulated by Wnt signal.