Evolution of the somatotopic map in the vertebrate hindbrain

脊椎动物后脑体位图的进化

• 批准号: 22770218
• 负责人: MURAKAMI Yasunori
• 金额: $ 2.83万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22770218/
• 关键词: 進化; 脳・神経; 発生・分化; 遺伝子; 解剖学; 脳・神

To identify the evolutionary process of somatotopic organization in vertebrate trigeminal system, we compared trigeminal nerve organization in developing turtle, chick, and mouse. We found that, while mandibular and maxillary branch somatotopy is conserved in turtle, these branches in the chick are not strictly spatially segregated, and their position in the trigeminal tract is inversed, as compared to mouse. Furthermore, by using this specific marker in combination with Hoxa2 and axonal tracings from the periphery, we mapped the position of chick PrV in rhombomere(r) 1, unlike mouse PrV that mainly maps in r2-r3. Thus, somatotopy of trigeminal ganglion and nerve organization is only partially conserved through amniote evolution, possibly in relation to the modification of facial somatosensory structures and morphologies.

为了明确脊椎动物三叉神经系统中躯体位置组织的进化过程，我们比较了发育中的龟、鸡和小鼠的三叉神经组织。我们发现，虽然下颌骨和上颌分支的躯体形态是保守的乌龟，这些分支在小鸡没有严格的空间隔离，和它们的位置在三叉神经束是颠倒的，相比，小鼠。此外，通过使用这种特异性标记物与Hoxa 2和来自外周的轴突示踪相结合，我们绘制了鸡PrV在菱形节（r）1中的位置，而不像小鼠PrV主要在r2-r3中绘制。因此，三叉神经节和神经组织的躯体解剖学仅部分地通过神经元进化而被保存，这可能与面部躯体感觉结构和形态的改变有关。

项目成果

円口類に脊椎動物の脳の原型を見出し、何が大脳を進化させたかを考察する

发现圆口类脊椎动物大脑的原型并思考是什么导致了大脑的进化

• 发表时间: 2011
• 作者: Yasuhiro Yokota;Daisuke Saito;Ryosuke Tadokoro;Yoshiko Takahashi;土佐靖彦・川口将史・長島寛・川崎能彦・平田たつみ・村上安則;Y. Murakami
• 通讯作者: Y. Murakami

Disruption of Sema3A expression causes abnormal neural projection in heavy oil exposed Japanese flounder larvae.

• DOI: 10.1016/j.marpolbul.2011.01.022
• 发表时间: 2011
• 期刊: Marine pollution bulletin
• 影响因子: 5.8
• 作者: Masahumi Kawaguchi;Jun-Young Song;K. Irie;Y. Murakami;K. Nakayama;S. Kitamura

脊椎動物における小脳神経回路の進化

脊椎动物小脑神经回路的进化

• 发表时间: 2011
• 作者: Shigehiro Yamada;Kohji Hotta;Takamasa S.Yamamoto;Naoto Ueno;Nori Satoh;Hiroki Takahashi;Ochi H. and Ogino H.;川口将史
• 通讯作者: 川口将史

Effect of heavy oil on the development of the nervous system of floating and sinking teleost eggs

• DOI: 10.1016/j.marpolbul.2011.04.018
• 发表时间: 2011-01-01
• 期刊: MARINE POLLUTION BULLETIN
• 影响因子: 5.8
• 作者: Irie, Kouta;Kawaguchi, Masahumi;Murakami, Yasunori
• 通讯作者: Murakami, Yasunori

Nervous system disruption and concomitant behavioral abnormality in early hatched pufferfish larvae exposed to heavy oil

• DOI: 10.1007/s11356-012-0833-0
• 发表时间: 2012-08-01
• 期刊: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
• 影响因子: 5.8
• 作者: Kawaguchi, Masahumi;Sugahara, Yuki;Murakami, Yasunori
• 通讯作者: Murakami, Yasunori