Synthetic study on bioactive natural product, causing hatching phenomenon toward potato Cyst nematodes, by construction of highly-substituted cyclobutane skeleton

点击翻译按钮获取中文摘要

Synthesis of solanoeclepin A, the most active hatching agent of potato cyst nematode isolated from hydroponic potato cultures was examined not only for the chemical supply of solanoeclepin A but also for the structure-activity relationship study. As a result, the new ring expansion reaction was discovered for the synthesis of a chiral hexahydroazulene skeleton possessing an angular methyl group. Furthermore, synthesis of oxabicylo skeleton, corresponding to the left-hand nucleus, was also achieved.