Regulation of immune state in adipose tissue associated with life style diseases by food components

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In the present study, I clarified the immune cells infiltrated into adipose tissues in the progression of obesity, and explored the food components which can improve the immune state in obese adipose tissues. As a result, T cells and mast cells, as well as macrophages, were infiltrated into obese adipose tissues, and I found the involvement of mast cells in fibrosis of obese adipose tissues. I further demonstrated that food-derived carotenoids, astaxanthin and canthaxanthin, could improve glucose intolerance in obese mice by the inhibition of adipocyte differentiation, which suppressed the aggravation of immune state in obese adipose tissues.