Clarification of local GnRH-induced luteolysis in the rat ovaryand challenge to control thecorpus luteumlife span

如果直到发情间期第二天下午催乳素供应不足，黄体就会迅速退化。在这项研究中，我们重点研究了特定时间决定大鼠黄体寿命的机制。最后，我们阐明了1)局部促性腺激素释放激素可以改变黄体催乳素受体亚型的表达比例，2)我们可以通过人为地改变该表达比例来控制黄体期的持续时间。

Thecorpusluteum regresses rapidlyif prolactin is not adequately supplied until the afternoon on diestrus 2.In this study, we focused onthemechanisms of time-specific determinationof thecorpus luteum life span in rats. Eventually, we clarified that1) local gonadotropin-releasing hormone could alter the expression ratio of prolactin receptor isoforms in corpus luteum, and 2) we could control theduration of luteal phase by changing that expression ratioartificially.