Clarification of local GnRH-induced luteolysis in the rat ovaryand challenge to control thecorpus luteumlife span

如果催乳素供应不足，直到第二天下午，肌体退化迅速。本研究主要探讨大鼠黄体寿命的时间特异性决定机制。结果表明：1)局部促性腺激素释放激素可改变黄体泌乳素受体异构体的表达比例；2)可通过人为改变其表达比例来控制黄体期的持续时间。

Thecorpusluteum regresses rapidlyif prolactin is not adequately supplied until the afternoon on diestrus 2.In this study, we focused onthemechanisms of time-specific determinationof thecorpus luteum life span in rats. Eventually, we clarified that1) local gonadotropin-releasing hormone could alter the expression ratio of prolactin receptor isoforms in corpus luteum, and 2) we could control theduration of luteal phase by changing that expression ratioartificially.