Strategy for therapy of atherosclerotic plaque by drug delivery system using immune-liposomes

制备了识别动脉粥样硬化斑块中巨噬细胞和泡沫细胞的抗LOX1抗体修饰的脂质体(LOX1-脂质体)，并检测了其治疗动脉粥样硬化的疗效。LOX1脂质体对小鼠动脉粥样硬化斑块的靶向效率高于未修饰脂质体。此外，含有抗动脉粥样硬化药物的LOX1脂质体显著减少了小鼠的动脉粥样硬化斑块。本研究提示LOX1脂质体有可能成为治疗动脉粥样硬化斑块的新策略。

Liposomes modified with anti-LOX1antibody(LOX1-liposomes) which recognizes macrophages and foam cells in atherosclerotic plaque were prepared and their efficacy for atherosclerotic therapy was examined. Targeting efficiency of LOX1-liposomes to atherosclerotic plaque of mice was greater than that of non-modified liposomes. Also, LOX1-liposomes containing anti-atherosclerotic drug significantly reduced atherosclerotic plaque of mice. This study suggests that LOX1-liposomes may be a new strategy for therapy of atherosclerotic plaque.