Development of rapid methylation reaction using polymer supported palladium complex

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It is important issue to ensure the safety of PET probes because which is finally give to human clinical study. Carbon-carbon bonding formation is widely used to synthesize PET probes because C-C bond is stable than C-N, C-O or C-S bond in vivo system. Though, in many cases, an organometallic complex is required to form the C-C bond. In order to prevent contamination of the metal complex to the final product for clinical use, solid phase reaction using solid supported palladium complex have examined.