Analysis of input signal specific to mammalian circadian center

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In order to investigate signals transmitted in the suprachiasmatic nucleus(SCN), perturbation of cAMP signal by chronic administration of Forskolin(FK) to Per2 :: Luc rat SCN slice was performed. Administration of FK divided the SCN into two regions based on the period length. One of which showed shorter period than 24 h(SPR) and another showed longer than 24 h(LPR). SPR was localized in the medial region of the dorsal SCN and LPR localized in the lateral region, respectively. Intriguingly, the SPR and a region where phase wave starts were overlapped. These results suggest that cAMP dependent signal is involved in the synchronization of the SCN subregions. Further study of SPR may lead to the understanding of unknown mechanisms and roles of the phase wave in the mammalian circadian center.