Research on Epidermal Cell Differentiation Inhibitor EDIN producing Staphylococcus aureus

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Biological activity was checked for recombinant ETs and EDINs producing by staphylococcus aureus, using the ICR mouse and the cultured cell.Next, in order to examine the diffusibility from the mouse skin of these toxins to the whole body, it analyzed by trans-well using skin structure.As a result, the diffusibility to the lower layer of ET was accepted also under which conditions. What the skin shifted, the crevice was made and division of up-and-down culture solution had not carried out when this equipped with skin structure was considered to be the cause.