Establishment of the evaluation of early development of atherosclerosis in obesity and metabolic syndrome-focus on the fraction of fatty acid and function of monocytes-

我们从国立医院组织数据库中的1050名日本肥胖和代谢综合征患者中阐明了脂肪酸与已知的心血管风险和外周血单核细胞功能(炎性M1型和抗炎性M2型)显著相关。此外，我们还阐明了二十碳五烯酸(EPA)对肥胖患者单核细胞不利的M1/M2样表型的抗炎作用及其机制。现在，我们正在阐明影响单核细胞脂肪酸组成和表型的单核苷酸多态。因此，脂肪酸组分和单核细胞表型的测定对肥胖和代谢综合征患者动脉粥样硬化的早期发现和心血管疾病的预防是有用的。

We have elucidated that the fraction of fatty acids was significantly associated with the known cardiovascular risks and the function of peripheral blood monocytes(inflammatory M1 type and anti-inflammatory M2 type) in Japanese patients with obesity and metabolic syndrome from 1050 subjects in the database of National Hospital Organization. In addition, we have clarified the anti-inflammatory effect and its mechanism of eicosapentaenoic acid(EPA) on unfavorable M1/M2-like phenotypes of monocytes in obesity. Now, we are elucidating the single nucleotide polymorphisms which affect the fraction of fatty acids and phenotypes of monocytes. Accordingly, these data suggests the usefulness of the measu rement of the fraction of fatty acids and phenotypes of monocytes for early detection of atherosclerosis and the prevention of cardiovascular diseases in obesity and metabolic syndrome.