Novel molecular-targeting prevention of cancer by inducers of TRAIL release

我们评估了几种免疫调节剂是否刺激了中性粒细胞释放TRAIL。结果，丁酸梭菌MIYAIRI 588（CBM 588）增加了PMN培养上清液中可溶性TRAIL水平。有趣的是，TLR 2/4信号通路被认为是MMP-8释放TRAIL的重要途径。我们证明了CBM 588增强了PMNs对人膀胱癌细胞的细胞毒性。此外，已证明CBM 588通过在体内以及体外诱导细胞凋亡而对癌细胞有效。

We evaluated whether several immunomodulators stimulated the release of TRAIL from PMNs. As a result, Clostridium butyricum MIYAIRI 588(CBM588) increased soluble TRAIL levels in the culture supernatant of PMNs. Interestingly, TLR2/4 signaling pathway has been suggested to be important for the release of TRAIL by MMP-8.We demonstrated that CBM588 enhanced the cytotoxicity of PMNs against human bladder cancer cells. In addition, CBM588 has proven effective against cancer cells by inducing apoptosis in vivo as well as in vitro.