Research the possibility of the traditional Japanese medicine"Rikkunshito" as the calorie restriction mimetic drug

日本传统药物“利空食(RKT)”的短期治疗可增加血浆乙酰胃促生长素，并通过下丘脑NPY表达刺激食物摄取。这一机制类似于卡路里限制(CR)。在这项研究中，我们研究了RKT作为热量限制模拟药物的可能性。慢性RKT治疗可增加酰基-Ghrelin水平，增强抗氧化应激能力，与CR的作用相似。然而，慢性RKT治疗并不能延长生命。有趣的是，从中老年开始的慢性RKT治疗明显减少白色脂肪组织质量，尽管在老年模型中RKT治疗的更多细节条件和分子机制还有待阐明，但仍有望应用抗肥胖药物。

Short term treatment of traditional Japanese medicine “Rikkunshito (RKT)” increases plasma acyl-ghrelin, and stimulates food intake via hypothalamic NPY expression. This mechanism is similar to that of calorie restriction (CR). In this study, we investigated the possibility of RKT as the calorie restriction mimetic drug. Chronic RKT treatment increased acyl-ghrelin level, and enhanced oxidative stress resistance like the effect of CR. However, chronic RKT treatment could not extend lifespan. Interestingly, chronic RKT treatment from middle or old age significantly decreased white adipose tissue mass.Although it is necessary to clear more detail condition and molecular mechanisms of RKT treatment at the old age model, it is expected to apply anti-obesity drug.