Research the possibility of the traditional Japanese medicine"Rikkunshito" as the calorie restriction mimetic drug

研究日本传统药物“六君子”作为卡路里限制模拟药物的可能性

• 批准号: 22790620
• 负责人: KOMATSU Toshimitsu
• 金额: $ 2.5万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790620/
• 关键词: 東洋医学; カロリー制限; 抗老化

Short term treatment of traditional Japanese medicine “Rikkunshito (RKT)” increases plasma acyl-ghrelin, and stimulates food intake via hypothalamic NPY expression. This mechanism is similar to that of calorie restriction (CR). In this study, we investigated the possibility of RKT as the calorie restriction mimetic drug. Chronic RKT treatment increased acyl-ghrelin level, and enhanced oxidative stress resistance like the effect of CR. However, chronic RKT treatment could not extend lifespan. Interestingly, chronic RKT treatment from middle or old age significantly decreased white adipose tissue mass.Although it is necessary to clear more detail condition and molecular mechanisms of RKT treatment at the old age model, it is expected to apply anti-obesity drug.

日本传统药物“Rikkunshito（RKT）”的短期治疗增加血浆酰基-ghrelin，并通过下丘脑NPY表达刺激食物摄入。这种机制类似于卡路里限制（CR）。在本研究中，我们探讨了RKT作为热量限制模拟药物的可能性。慢性RKT治疗增加酰基-ghrelin水平，并增强氧化应激抵抗力，如CR的效果。然而，长期RKT治疗不能延长寿命。值得注意的是，从中老年开始的长期RKT治疗可显著降低白色脂肪组织质量，尽管RKT治疗老年模型的更详细情况和分子机制尚需明确，但其有望应用于减肥药物。

项目成果

FoxO1 is involved in the antineoplastic effect of calorie restriction

• DOI: 10.1111/j.1474-9726.2010.00563.x
• 发表时间: 2010-06
• 期刊: Aging Cell
• 影响因子: 7.8
• 作者: H. Yamaza;Toshimitsu Komatsu;Saori Wakita;Carole Kijogi;Seongjoon Park;H. Hayashi;T. Chiba;Ryoichi Mori;T. Furuyama;N. Mori;I. Shimokawa

Acute stress response modified by modest inhibition of growth hormone axis : apotential machinery of the anti-aging effect of calorie restriction

通过适度抑制生长激素轴来改变急性应激反应：热量限制的抗衰老作用的潜在机制

• DOI: 10.1016/j.mad.2011.01.002
• 发表时间: 2011
• 期刊: Mechanisms of Ageing and Development
• 影响因子: 5.3
• 作者: Komatsu T;Trindade LS;Chiba T;Hayashi H;Henmi T;Ushiroda Y;Mori R;Shimokawa I
• 通讯作者: Shimokawa I

Modulators of neuropeptide Y; potential dietary restriction mimetics

神经肽Y调节剂；

• 发表时间: 2012
• 作者: Yamaza H;Komatsu T;et al;Isao Shimokawa
• 通讯作者: Isao Shimokawa

Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species geeration or redox state, unlike calorie restriction

与热量限制不同，生长激素轴的适度抑制不会影响线粒体活性氧的生成或氧化还原状态

• 发表时间: 2011
• 期刊: Geriatr Gerontol Int
• 影响因子: 3.3
• 作者: Hayashida T;Komatsu T;et al
• 通讯作者: et al

Does a traditional Japanese medicine "Rikkunshito" promote stress resistance like calorie restriction?

日本传统药物“六君子”是否可以像限制热量一样促进抗压能力？

• 发表时间: 2011
• 作者: Taisuke Kasuya;Toshimitsu Komatsu
• 通讯作者: Toshimitsu Komatsu