Analysis of the relationship between IL28B SNP and HCV genome
Analysis of the relationship between IL28B SNP and HCV genome
批准号:
22790646
负责人:
ABE Hiromi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
The current standard treatment for patients chronically infected with HCV is the combination of peg-interferon(PEG-IFN) and ribavirin(RBV). It has been reported that genetic variations within IL28B gene are associated with the effect of the PEG-IFN and RBV combination therapy. In this study, we investigated the expression levels of interferon related genes in the liver using liver biopsy from HCV patients before the treatment. We reported that the expression levels of anti-viral genes are lower, but those of negative regulator in IFN signaling are higher in favorable IL28B genotype patients.
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Severe Necroinflammatory Reaction Caused by Natural Killer By Fas/ FasLInteraction and Dendritic Cells in Human Hepatocyte Chimeric Mouse
Fas/FasL相互作用与自然杀伤剂与人肝细胞嵌合小鼠树突状细胞引起的严重坏死性炎症反应
DOI:
--
发表时间:
2012
期刊:
Hepatology. In press
影响因子:
--
作者:
[Okazaki A, Hiraga N, Imamura M, Hayes CN, Tsuge M, Takahashi S, Aikata H, Abe H, Miki D, Ochi H, TatenoC, Yoshizato K, Ohdan H, Chayama K]
通讯作者:
Chayama K
DOI:
10.3851/imp1674
发表时间:
2010-01-01
期刊:
ANTIVIRAL THERAPY
影响因子:
1.2
作者:
[Kitamura, Shosuke, Tsuge, Masataka, Chayama, Kazuaki]
通讯作者:
Chayama, Kazuaki
DOI:
10.1093/infdis/jir210
发表时间:
2011-07-01
期刊:
JOURNAL OF INFECTIOUS DISEASES
影响因子:
6.4
作者:
[Chayama, Kazuaki, Hayes, C. Nelson, Kumada, Hiromitsu]
通讯作者:
Kumada, Hiromitsu
Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virus
病毒氨基酸取代和宿主IL28B多态性对丙型肝炎病毒复制和干扰素敏感性的影响
DOI:
--
发表时间:
2011
期刊:
Hepatology
影响因子:
13.5
作者:
[Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N, Chayama K]
通讯作者:
Chayama K
C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連
PegIFN/RBV治疗慢性丙型肝炎患者的疗效及IL28位点SNP与肝内IFN诱导基因表达水平的关系
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰]
通讯作者:
茶山一彰
共 40 条
An Interdisciplinary Reconsideration of Sensibility from a New Perspective on Sense(s) and Affect in the Long Eighteenth Century.
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批准号:18K00441
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2018
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负责人:ABE Hiromi
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依托单位:
ESTABLISHMENT AND ANALYSIS OF SOMATOSTATIN RECEPTORS (SSTR2 AND SSTR5) KNOCKOUT MOUSE
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批准号:08671162
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
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财政年份:1996
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负责人:ABE Hiromi
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依托单位:
CLONING OF GRF AND SOMATOSTATIN RECEPTOR cDNA : EXPRESSION IN PITUITARY ADENOMA OF ACROMEGALIC PATIENT.
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批准号:03671151
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:ABE Hiromi
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依托单位:
海外基金