Analysis of the relationship between IL28B SNP and HCV genome

IL28B SNP与HCV基因组关系分析

• 批准号: 22790646
• 负责人: ABE Hiromi
• 金额: $ 2.41万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790646/
• 关键词: 肝臓学; ヒトゲノム; ウイルス; ヒト肝細胞キメラマウス; ゲノム; 肝炎ウイルス

The current standard treatment for patients chronically infected with HCV is the combination of peg-interferon(PEG-IFN) and ribavirin(RBV). It has been reported that genetic variations within IL28B gene are associated with the effect of the PEG-IFN and RBV combination therapy. In this study, we investigated the expression levels of interferon related genes in the liver using liver biopsy from HCV patients before the treatment. We reported that the expression levels of anti-viral genes are lower, but those of negative regulator in IFN signaling are higher in favorable IL28B genotype patients.

目前慢性HCV感染患者的标准治疗是聚乙二醇干扰素（PEG-IFN）和利巴韦林（RBV）的联合治疗。据报道，IL28B基因的遗传变异与PEG-IFN和RBV联合治疗的效果有关。在这项研究中，我们在治疗前通过肝活检研究了HCV患者肝脏中干扰素相关基因的表达水平。我们报道了在有利的IL28B基因型患者中，抗病毒基因的表达水平较低，但IFN信号负调节基因的表达水平较高。

项目成果

Severe Necroinflammatory Reaction Caused by Natural Killer By Fas/ FasLInteraction and Dendritic Cells in Human Hepatocyte Chimeric Mouse

Fas/FasL相互作用与自然杀伤剂与人肝细胞嵌合小鼠树突状细胞引起的严重坏死性炎症反应

• 发表时间: 2012
• 期刊: Hepatology. In press
• 作者: Okazaki A;Hiraga N;Imamura M;Hayes CN;Tsuge M;Takahashi S;Aikata H;Abe H;Miki D;Ochi H;TatenoC;Yoshizato K;Ohdan H;Chayama K
• 通讯作者: Chayama K

Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy

• DOI: 10.3851/imp1674
• 发表时间: 2010-01-01
• 期刊: ANTIVIRAL THERAPY
• 影响因子: 1.2
• 作者: Kitamura, Shosuke;Tsuge, Masataka;Chayama, Kazuaki
• 通讯作者: Chayama, Kazuaki

IL28B But Not ITPA Polymorphism Is Predictive of Response to Pegylated Interferon, Ribavirin, and Telaprevir Triple Therapy in Patients With Genotype 1 Hepatitis C

• DOI: 10.1093/infdis/jir210
• 发表时间: 2011-07-01
• 期刊: JOURNAL OF INFECTIOUS DISEASES
• 影响因子: 6.4
• 作者: Chayama, Kazuaki;Hayes, C. Nelson;Kumada, Hiromitsu
• 通讯作者: Kumada, Hiromitsu

Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virus

病毒氨基酸取代和宿主IL28B多态性对丙型肝炎病毒复制和干扰素敏感性的影响

• 发表时间: 2011
• 期刊: Hepatology
• 影响因子: 13.5
• 作者: Hiraga N;Abe H;Imamura M;Tsuge M;Takahashi S;Hayes CN;Ochi H;Tateno C;Yoshizato K;Nakamura Y;Kamatani N;Chayama K
• 通讯作者: Chayama K

C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連

PegIFN/RBV治疗慢性丙型肝炎患者的疗效及IL28位点SNP与肝内IFN诱导基因表达水平的关系

• 发表时间: 2010
• 作者: 阿部弘美;越智秀典;柘植雅貴;三木大樹;光井富貴子;平賀伸彦;今村道雄;高橋祥一;茶山一彰
• 通讯作者: 茶山一彰