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Functional analysis of Ubiquitin ligase Itch in doxorubicin-induced cardiomyopathy

Functional analysis of Ubiquitin ligase Itch in doxorubicin-induced cardiomyopathy
泛素连接酶 Itch 在阿霉素诱导的心肌病中的功能分析
批准号：
22790684
负责人：
TAKAHASHI Hiroki
金额：
$2.16万
依托单位：
Yamagata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790684/
关键词：
ドキソルビシン心筋症ユビキチン転移酵素ItchアポトーシスUbiquitinationユビキチン転移酵素Itch

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英文摘要
In the present study, we focused on the interaction of ubiquitin E3 ligase Itch (a member of Ubiquitin-Proteasome system) and TXNIP to elucidate the mechanism for doxorubicin-induced cardiotoxicity. Knockdown of Itch attenuated doxorubicin-induced TXNIP degradation and subsequent increase in cleaved caspase-3. Furthermore, overexpression of Itch augmented doxorubicin-induced TXNIP degradation and resulted in reduction of cleaved caspase-3. These results suggest that Itch is one of potential target protein to prevent doxorubicin-induced cardiotoxicity.
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