Study on molecular mechanism causing cancer-associated retinopathy by aberrant expression of photoreceptor specific recoverin

光感受器特异性恢复蛋白异常表达导致癌症相关视网膜病变的分子机制研究

• 批准号: 22591945
• 负责人: OHGURO Hiroshi
• 金额: $ 2.83万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591945/
• 关键词: 癌関連網膜症; リカバリン; 異所性発現; 自己免疫; Ca^<2+>結合蛋白質; カベオリン; 網膜色素変性

T o elucidate the molecular pathology in CAR, expressions of recoverin were examined. Recoverin was identified to be expressed in 30-70% of cancer tissues. We observed co-precipitation of G-protein-coupled-kinases (GRKs) and caveolin-1 with Rec from cell lysates of 293 or SSTW cells. Immunocytechemistry revealed that immunoreactivitiestoward recoverin within the cancer cells were almost identical to those toward GRKs and caveolin-1. The present data strongly suggests that aberrantly expressed recoverin should be involved in the GRK-dependent cellular regulation in cancer cells.

为了阐明CAR的分子病理，我们检测了recoverin的表达。在30-70%的癌组织中发现有Recoverin表达。我们从293或SSTW细胞裂解物中观察到g蛋白偶联激酶（GRKs）和小窝蛋白-1与Rec共沉淀。免疫细胞化学显示，肿瘤细胞内对恢复的免疫反应性与对GRKs和caveolin-1的免疫反应性几乎相同。目前的数据强烈提示，异常表达的recoverin可能参与了grk依赖性的癌细胞细胞调节。

项目成果

A case of retro bulbar optic neuritis associated with anti-tumor necrosis factor (infliximab)

抗肿瘤坏死因子（英夫利昔单抗）相关的球后视神经炎一例

• 发表时间: 2011
• 作者: Wang Y;Hashimoto M;Hiraoka M;Tanaka S;Ohguro H
• 通讯作者: Ohguro H

Analysis of mRNA expressions of retinal angiogenic factors in SDTorii (SDT) rat

SDTorii(SDT)大鼠视网膜血管生成因子mRNA表达分析

• 发表时间: 2010
• 作者: Maeda K;Ishikawa F;Saito Y;Y oshida K;Inatomi S;Ohguro I;Ohguro H
• 通讯作者: Ohguro H

Selected topics in optical coherence tomography

光学相干断层扫描选题

• 发表时间: 2012
• 作者: Maruko I;Iida T;Sugano Y;Ojima A;Ogasawara M;五味 文;Katai M
• 通讯作者: Katai M

Low levels of plasma endothelin-1 in patients with retinitis pigmentosa

色素性视网膜炎患者血浆内皮素-1 水平低

• 发表时间: 2010
• 期刊: Clin Ophthalmol
• 影响因子: 2.2
• 作者: Ohguro H;Mashima Y;Nakazawa M
• 通讯作者: Nakazawa M

Vascular compressive optic neuropathy caused by hypertensive intracranial ophthalmic artery.

颅内眼动脉高血压引起的血管压迫性视神经病变。

• 发表时间: 2010
• 期刊: Jpn J Ophthalmol.
• 作者: Hikage F;Hashimoto M;Ohguro H
• 通讯作者: Ohguro H