A new regulative mechanism for monoamine transporter expression in plasma membrane : The participation of histamine H3 receptor

质膜单胺转运蛋白表达的新调控机制：组胺H3受体的参与

• 批准号: 22592065
• 负责人: SOGAWA Norio
• 金额: $ 2.83万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592065/
• 关键词: ヒスタミン H3 受容体(H3R); モノアミントランスポーター; ノルアドレナリントランスポーター(NET); ヒスタミンH3受容体; ノルアドレナリントランスポーター

To study the participation of histamine H3 receptor (H3R) on the transition of monoamine transporters into plasma membrane which is necessary to exert their function as transporters, we investigated the relation between H3R and noradrenaline transporter (NET) expression by using coexpressing cell system for both H3R and NET. The results which obtained from this experiment were suggested that there was a mechanism by which H3R inhibited the NET expression into the plasma membrane by binding to NET and making it fit tightly in the cell.

为研究组胺H3受体（H3R）参与单胺转运体向质膜转运的过程，探讨H3R与去甲肾上腺素转运体（NET）共表达细胞系统中H3R与NET表达的关系。本实验结果提示，H3R通过与NET结合，使其与细胞紧密贴合，从而抑制NET向质膜内的表达。

项目成果

Age-dependent changes in the susceptibility to thiopental anesthesia in mice: analysis of the relationship to the functional expression of GABA transporter

小鼠硫喷妥钠麻醉敏感性的年龄依赖性变化：与 GABA 转运蛋白功能表达关系的分析

• DOI: 10.1016/j.pbb.2012.08.027
• 发表时间: 2012
• 期刊: Pharmacology, Biochemistry and Behavior
• 作者: Norio Sogawa;Yuri Hazehara;Muneyoshi Kunitomo;Yuya Morita;Bupsang Yoo;Kazumi Ohyama;Chiharu Sogawa and Shigeo Kitayama
• 通讯作者: Chiharu Sogawa and Shigeo Kitayama

Post- transcriptional regulation of noradrenaline transporter by nicotine

尼古丁对去甲肾上腺素转运蛋白的转录后调节

• 发表时间: 2013
• 作者: Ohyama;K.;Sogawa;C.;Wen;X.;Morita;K.;Sogawa;N. and Kitayama;S
• 通讯作者: S

Nicotine regulation of the expression of noradrenaline transporter gene

尼古丁对去甲肾上腺素转运蛋白基因表达的调节

• 发表时间: 2012
• 作者: Chiharu Sogawa;Kazumi Ohyama;Xue-fang Wen;Norio Sogawa;Shigeo Kitayama
• 通讯作者: Shigeo Kitayama

ヒスタミンH3 受容体が示す各種抑制機能

组胺 H3 受体表现出的各种抑制功能

• 发表时间: 2010
• 作者: Sogawa C;Sogawa N;Kitayama S;十川紀夫
• 通讯作者: 十川紀夫

Immunocytochemical approaches to the identification of membrane topology of the Na+/Cl--dependent neurotrans- transmitter transporters

免疫细胞化学方法鉴定 Na /Cl 依赖性神经递质转运蛋白的膜拓扑

• 发表时间: 2012
• 作者: Sogawa C.;Sogawa N.;Kitayama S.;INTECH
• 通讯作者: INTECH