Cross-talk between innate-immunological responses and oral oncogenesis.

与对照载体相比，含有HIF-1的构建体的3 ' utr蛋白表达减少了约50%。特别是，与侵袭性较低的乳腺癌细胞系MCF7相比，高侵袭性乳腺癌细胞系MDA-MB-453表现出更高的蛋白表达。似乎HIF-1a mRNA的3'UTR依赖性降解在几种表明恶性表型的癌细胞中受到抑制。我们也在口腔鳞状细胞癌细胞中发现了相同的表型。因此，依赖3'UTR的mRNA降解调控可能在口腔癌的进展（血管诱导、侵袭或间质转化）中发挥重要作用。

Approximately 50% decreased protein expression was observed for3’UTR of HIF-1 containing constructs compared to the control vector. In particular, a highly-aggressive breast cancer cell line MDA-MB-453 demonstrated a higher protein expression compared to a less-aggressive breast cancer cell line MCF7. It is plausible that 3’UTR dependent degradation of HIF-1a mRNA is repressed in several cancer cells which indicate malignant phenotypes. We also found the same phenotype in oral squamous cell carcinoma cells. Thus, 3’UTR dependent regulation of mRNA degradation might play an important role in the progression (vascular induction, invasion oreptherial-mesenchymal transition) of oral cancers.