Development of new treatment in replantation of teeth used at hyperbaric oxygen therapy

高压氧治疗牙齿再植新疗法的开发

• 批准号: 22592143
• 负责人: TAKAHASHI Toshiyuki
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592143/
• 关键词: 高気圧酸素治療; 歯牙再植; 再植; スポーツ歯学; 外傷; ラット; 高気圧酸素療法; 抜歯; 創傷治癒

The aim of the present study was to investigate the effect of hyperbaric oxygen (HBO) on the healing of the replanted molar in rat. Group 1 consisted of rats which underwent HBO, and Group 2 consisted of rats receiving no treatment. Group2 rats were given HBO (100% oxygen at 2.5 atmosphere absolute) for 120 minutes per day for five days, beginning the day of surgery. The experimental tissues in both groups were removed at 7 day after operation. By histological evaluation, the HBO therapy seemed to increased microvessel density and fibroblast in periodontal tissues of replanted molar. It was suggested that HBO therapy has a positive effects on the healing of the replantedmolar in rat.

本研究旨在探讨高压氧（HBO）对大鼠再植磨牙愈合的影响。第1组为接受HBO治疗的大鼠，第2组为未接受治疗的大鼠。第2组大鼠从手术当天开始每天给予HBO（100%氧气，2.5大气压绝对压力）120分钟，持续5天。两组均于术后第7天取出实验组织。组织学观察显示高压氧治疗后再植磨牙牙周组织中微血管密度和成纤维细胞增加。提示高压氧治疗对大鼠再植磨牙的愈合有促进作用。