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The analysis of histone modification in 4NQO-induced rat tongue cancer model

The analysis of histone modification in 4NQO-induced rat tongue cancer model
4NQO诱导的大鼠舌癌模型中组蛋白修饰分析
批准号:
22592211
负责人:
YONEMOTO Kazuhiro
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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英文摘要
We aim to examine the usefulness of 4-NQO induced rat tongue cancer as human oral carcinogenesis model .In order to verify whether changes in the overall level of H3K4,H3K9 histone methylation,the level of H3K4me3,H3K9me2,me3 were measured in 4-NQO induced rat tongue cancer model by western blotting.Our results suggest that the level of H3K9me2 was increased in squamous cell carcinoma of rat at 32 weeks from beginning of administration.Therefore, 4-NQO induced rat tongue cancer model is suggested the usefulness as human oral carcinogenesis model .
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