Analysis of inhibiting the invasion and metastasis in oral squamous cell carcinoma

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The aim of this study was to develop a new method of inhibiting the invasion and metastasis of oral squamous cell carcinoma (OSCC) through the activating KCNJ2-Lin7C-CASK-βcatenin pathway. As the result of suppressed expression of KCNJ2 which located upstream of βcatenin, βcatenin expression levels were increased. In addition, we identified some molecules of upstream of KCNJ2 by the Ingenuity Pathway Analysis, and then focused amiodarone which is the drug of ventricular tachycardia. After treatment with this drug, expression levels of Lin7C, CASK and βcatenin were significantly up-regulated. We suggested that the specific KCNJ2 inhibitor, amiodarone, closely related to KCNJ2-Lin7C-CASK-βcatenin pathway, and therefore might be a therapeutic agent for cancer invasion and metastasis.