Modulatory influence of ovariectomy on orofacial neuropathic pain in rats

采用von Frey试验，研究了葛沙净冲剂对去卵巢大鼠眶下神经损伤后机械超敏反应的影响。结果表明，GJG慢性给药具有渐进性镇痛作用的潜能。此外，卵巢切除组与假手术组之间存在明显差异，因此卵巢切除本身可能会降低GJG的镇痛作用。在同一模型中对雌二醇(ES)替代的影响的检查表明，ES可加重急性炎症，同时缓解慢性疾病，如神经病理性疼痛。

We studied the effects of goshajinkigan (GJG) on mechanical hypersensitivity in ovariectomized rats with infraorbital nerve injury using the von Frey test. The results showed the potential development of gradual analgesic action with chronic administration of GJG. In addition, a difference was apparent between the ovariectomy and sham operation groups, and thus ovariectomy itself may reduce the analgesic effect induced by GJG. Examination of the effects of estradiol (Es) replacement in the same model indicated that Es acted to aggravate acute inflammation while mitigating chronic conditions such as neuropathic pain.