Study of insulin resistance on oral mucosa disease and hepatitis C? role of a dentist

在日本，有超过200万丙型肝炎病毒（HCV）感染者。HCV感染是美国最大的感染。另一方面，HCV引起各种肝外表现以及肝脏疾病。口腔扁平苔藓、干燥综合征是肝外表现的代表性疾病。发现HCV感染引起的胰岛素抵抗不仅与口腔癌有关，而且与多种原发性肿瘤有关。（1）牙齿问题延迟了HCV感染患者干扰素（IFN）治疗的开始;（2）富含支链氨基酸（BCAA）的干扰素（包括锌）改善了HCV感染肝病患者的味觉敏感性;（3）HCV相关慢性肝病IFN治疗期间和治疗后的口腔粘膜病变和其他口腔粘膜病变。（4）日本HCV感染和OLP的回顾性病例对照研究：HCV核心区和N5 A区突变的相关性研究。

In Japan, there are over two million hepatitis C virus (HCV) infected people. HCV infection is the nation's largest infection. On the other hand, HCV causes various kinds of extrahepatic manifestations as well as liver diseases. Oral lichen planus (OLP), Sjogren's syndrome are the representative diseases of extrahepatic manifestations. It was found that an insulin resistance that HCV infection caused was associatedwith not only oralcancerbut alsothemultipleprimaryneoplasm.Furthermore, we clarified follows: (1) Dental problems delaying the initiation of interferon (IFN) therapy for HCV-infected patients, (2) branched-chain amino acids (BCAA)-enriched supplementincludingzincimprovesthesensitivitytotasteinpatientswith HCV-infected liver disease, (3) Candidiasis and other oral mucosal lesions during and after IFN therapy for HCV-related chronic liver diseases, (4) A retrospective case-control study of HCV infection and OLP in Japan: association study with mutations in the core and N5A region of HCV.