MRI quantification of cerebral blood flow and oxygen metabolism at rest and during task performance --- to elucidate the sensing mechanism of fatigue in the brain

静息和任务执行过程中脑血流量和氧代谢的MRI量化——阐明大脑疲劳的感知机制

• 批准号: 22613003
• 负责人: TOYODA Hiroshi
• 金额: $ 2.08万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22613003/
• 关键词: MRI; 局所脳血流量; 疲労

The purpose of this study was to develop a non-invasive method for functional brain imaging both at rest and during tasks, in order to elucidate the sensing mechanisms of fatigue in the human brain. Healthy subjects were measured by a newly developed MRI-based spin labeling methods to quantify cerebral blood flow and oxygen extraction fraction at baseline. The pulse sequences for arterial spin labeling were optimized using multi-slab 3D acquisitions, the measurement accuracy of which was validated. The feasibility of the proposed method was demonstrated by its better time efficiency without sacrificing quantification accuracy.

本研究的目的是开发一种非侵入性的方法，在休息和任务过程中的功能脑成像，以阐明在人类大脑的疲劳感测机制。健康受试者通过新开发的基于MRI的自旋标记方法来定量基线时的脑血流量和氧提取分数。使用多层3D采集优化了动脉自旋标记的脉冲序列，并验证了其测量精度。在不牺牲定量准确度的前提下，该方法具有更好的时间效率，证明了该方法的可行性。

项目成果

Automatic segmentation method using T1- and T2-weighted images without any tissue probability maps

使用 T1 和 T2 加权图像的自动分割方法，无需任何组织概率图

• 发表时间: 2010
• 作者: Hiroshi Toyoda;Yasuyoshi Watanabe
• 通讯作者: Yasuyoshi Watanabe

Interleaved multi-slab 3D gradient and spin echo for arterial spin labeling

用于动脉自旋标记的交错多板 3D 梯度和自旋回波

• 发表时间: 2013
• 作者: Hiroshi Toyoda;Guoxian Liu;Yusuke Morito;Yasuyoshi Watanabe
• 通讯作者: Yasuyoshi Watanabe

Suppression of brain activity related to a car-following task with an auditory task: An fMRI study

• DOI: 10.1016/j.trf.2011.11.002
• 发表时间: 2012-01-01
• 期刊: TRANSPORTATION RESEARCH PART F-TRAFFIC PSYCHOLOGY AND BEHAVIOUR
• 影响因子: 4.1
• 作者: Uchiyama, Yuji;Toyoda, Hiroshi;Sadato, Norihiro
• 通讯作者: Sadato, Norihiro