Regulation mechanisms of mechanostress-induced actin cytoskeleton reorganzation

在这项研究中，我们研究了机械应力诱导肌动蛋白细胞骨架重塑的分子机制。我们成功地鉴定了8个Rho-GEFs参与血管内皮细胞循环拉伸诱导的细胞排列，5个Rho-GEFs参与乳腺上皮细胞细胞外基质诱导的上皮-间质转化（EMT）样转化的刚性。我们还发现p63RhoGEF在极化细胞迁移中起着至关重要的作用。

In this study, we investigated the molecular mechanisms of mechanostress-induced actin cytoskeleton remodeling. We succeeded in identifying 8Rho-GEFs involved in cyclic stretch-induced cell alignment of vascular endothelial cells and 5 Rho-GEFs involved in the rigidity of extracellular matrix-induced epithelial-mesenchymal transition (EMT) -like transformation in mammary epithelial cells. We also revealed that p63RhoGEF is plays a crucial role in the polarized cell migration.