An attempt to deal with saturated fatty acid-induced insulin resistance by the stiffness of the extracellular matrix

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We previously reported that 3T3-L1 adipocytes exhibit palmitate-induced proinflammatory response most prominently, when they are seeded on 2 -D matrices, which have a stiffness that correspond to that of obese adipose tissues. We then analyzed how mechanical properties of the matrices affect adipocyte functions, when they are seeded in a 3-D environment. Here we report that not only the stiffness of the matrices but also compression of the matrices regulate adipocyte functions.