Basic research of a brain functional magnetic resonance imaging based on restrictive water diffusion by using a q-space imaging method

本研究的目的是寻求一种新的Q空间磁共振成像(QSI)方法在检测大鼠脑内神经活动方面的应用。在本研究中，我们试图利用QSI方法对大脑中动脉阻塞(MCAO)大鼠模型进行影像分析，并利用峰度图显示缺血区。此外，还优化了活动诱导锰增强磁共振成像(AIM-MRI)作为确认大鼠在体脑内神经活动的工具。这项初步研究的结果表明，QSI是一种有用的工具，用于大鼠脑内的非侵入性神经成像分析，尽管还需要进一步的研究。

The purpose of this study was to seek application of a novel q-space magnetic resonance imaging(QSI) method for detecting neural activity in rat brain. In this study, we attempted to utilize the QSI method to an imaging analysis of middle cerebral artery occlusion(MCAO) rat model as an initial work and to visualize ischemic area by using "Kurtosis" mapping. Furthermore, activity induced manganese enhanced magnetic resonance imaging(AIM-MRI) was also optimized as a tool to confirm the neural activity in rat brain in vivo. Results of this initial study suggest that the QSI is a useful tool for noninvasive neuroimaging analysis in rat brain, albeit further study is needed.