Establishment of noninvasive neuroimaging analysis in experimental animals by using diffusion weighted magnetic resonance imaging.

本研究的目的是建立一个无创的成像分析，以检测神经退行性变的实验动物，通过使用磁共振（MR）成像。在这项研究中，锰增强磁共振成像作为一种工具，描绘正常的神经通路在非人灵长类动物在体内进行了优化。此外，进行扩散张量MR成像以检测动物视网膜投射通路的变性。本研究的结果表明，扩散加权磁共振成像是一个有用的工具，在实验动物的非侵入性神经影像分析。

The purpose of this study was to establish a noninvasive imaging analysis for detecting neural degeneration in the experimental animals by using magnetic resonance (MR) imaging. In this study, manganese enhanced MR imaging was optimized as a tool to depict the normal neural pathways in non-human primates in vivo. Furthermore, diffusion tensor MR imaging was performed to detect the degeneration on the retinal projection pathways of the animals. Results of this study suggest that diffusion weighted MR imaging is a useful tool for noninvasive neuroimaging analysis in the experimental animals.