Tailor-made exercise therapy based on gene polymorphism for improvement of arterial stiffness

点击翻译按钮获取中文摘要

The present study provides a cross-sectional investigation of 763-843 Japanese men and women (18-70 years old) to clarify the effects of cardiorespiratory fitness on the relationship between arterial stiffness and 5,10-methylene tetrahydrofolate reductase (MTHFR) C677T and fatty-acid binding protein 2 (FABP2) Ala54Thr gene polymorphisms. Arterial stiffness was assessed by carotid β -stiffness with urtrasonography and tonometry. The study subjects were divided into High-Fit and Low-Fit groups based on the median value of peak oxygen uptake in each gender and decade. The plasma homocysteine level was higher in the TT genotype of MTHFR C677T polymorphism compared with CC and CT genotype individuals. There was no effect of MTHFR C677T polymorphism on carotid β-stiffness, but was significant interaction effect fitness and MTHFR C677T polymorphism on carotid β-stiffness (P = 0.0017). In the Low-Fit subjects, carotid β-stiffness was significantly higher in TT genotype individuals than in CC and CT genotypes. However, there were no such differences in High-Fit subjects. In addition, there were no significant effect of FABP2 Ala54Thr polymorphism on carotid beta-stiffness and blood pressure. Carotid β-stiffness, systolic blood pressure, and diastolic blood pressure in the Low-Fit subjects increased in AlaAla genotype individuals compared with AlaThr and ThrThr genotype of FABP2 Ala54Thr, however, had no effect on FABP2 gene polymorphismsin High-Fit subjects. These results suggest that the higher cardiorespiratory fitness may attenuate the central artery stiffening associated with MTHFR C677T and FABP2 Ala54Thr polymorphisms.