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Tailor-made exercise therapy based on gene polymorphism for improvement of arterial stiffness

基于基因多态性的定制运动疗法改善动脉僵硬度

基本信息

批准号：
22650166
负责人：
IEMITSU Motoyuki
金额：
$ 2.23万
依托单位：
Ritsumeikan University (2011-2012)International Pacific University (2010)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

The present study provides a cross-sectional investigation of 763-843 Japanese men and women (18-70 years old) to clarify the effects of cardiorespiratory fitness on the relationship between arterial stiffness and 5,10-methylene tetrahydrofolate reductase (MTHFR) C677T and fatty-acid binding protein 2 (FABP2) Ala54Thr gene polymorphisms. Arterial stiffness was assessed by carotid β -stiffness with urtrasonography and tonometry. The study subjects were divided into High-Fit and Low-Fit groups based on the median value of peak oxygen uptake in each gender and decade. The plasma homocysteine level was higher in the TT genotype of MTHFR C677T polymorphism compared with CC and CT genotype individuals. There was no effect of MTHFR C677T polymorphism on carotid β-stiffness, but was significant interaction effect fitness and MTHFR C677T polymorphism on carotid β-stiffness (P = 0.0017). In the Low-Fit subjects, carotid β-stiffness was significantly higher in TT genotype individuals than in CC and CT genotypes. However, there were no such differences in High-Fit subjects. In addition, there were no significant effect of FABP2 Ala54Thr polymorphism on carotid beta-stiffness and blood pressure. Carotid β-stiffness, systolic blood pressure, and diastolic blood pressure in the Low-Fit subjects increased in AlaAla genotype individuals compared with AlaThr and ThrThr genotype of FABP2 Ala54Thr, however, had no effect on FABP2 gene polymorphismsin High-Fit subjects. These results suggest that the higher cardiorespiratory fitness may attenuate the central artery stiffening associated with MTHFR C677T and FABP2 Ala54Thr polymorphisms.

本研究对 763-843 名日本男性和女性（18-70 岁）进行了横断面调查，以阐明心肺健康对动脉僵硬度与 5,10-亚甲基四氢叶酸还原酶 (MTHFR) C677T 和脂肪酸结合蛋白 2 (FABP2) Ala54Thr 基因多态性之间关系的影响。动脉僵硬度通过超声检查和眼压测量的颈动脉β-硬度来评估。根据每个性别和十年的峰值摄氧量中值，研究对象被分为高健康组和低健康组。 MTHFR C677T 多态性 TT 基因型个体的血浆同型半胱氨酸水平高于 CC 和 CT 基因型个体。 MTHFR C677T 多态性对颈动脉 β 硬度没有影响，但健康度和 MTHFR C677T 多态性对颈动脉 β 硬度有显着的交互作用（P = 0.0017）。在 Low-Fit 受试者中，TT 基因型个体的颈动脉 β 硬度显着高于 CC 和 CT 基因型个体。然而，在 High-Fit 受试者中不存在这种差异。此外，FABP2 Ala54Thr 多态性对颈动脉 β 硬度和血压没有显着影响。与 FABP2 的 AlaThr 和 ThrThr 基因型个体相比，Low-Fit 受试者的颈动脉 β-僵硬度、收缩压和舒张压在 Low-Fit 受试者中有所增加，但 Ala54Thr 对 FABP2 基因多态性没有影响。这些结果表明，较高的心肺健康可能会减轻与 MTHFR C677T 和 FABP2 Ala54Thr 多态性相关的中央动脉硬化。