Irreversible electroporation as a medical treatment without thermal damage to extracellular matrix

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The irreversible electroporation(IRE) is a novel method to ablate abnormal cells by applying a high voltage between two electrodes that are stuck into abnormal tissues. One of the advantages of the IRE is that the extracellular matrix(ECM) may be kept intact, which is favorable for healing. For a successful IRE, it is therefore important to necrotize cells between electrodes without thermal damage to ECM resulted from the Joule heating within the tissue. In the present study, threedimensional(3-D) analyses were conducted to predict temperature rise during the IRE. A new method for measuring instant temperature rise using temperaturesensitive ink was also developed for validating the simulated results.