Screening and analysis of genes involved in regulation of lysosomal dynamics

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Lysosomes are membrane organelles responsible for degradation of various macromolecules. Fusion of lysosomes with other membrane organelles is critical for the lysosomal degradation ; however, the molecular mechanism underlying the lysosomal fusion is poorly understood. In the present study, I performed genetic screening for genes involved in regulation of lysosomal dynamics using the nematode C. elegans as a model organism and found that the small GTPase Arl8 may cooperatively function with the HOPS complex to regulate lysosomal fusion.