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A challenge for the Quality Control of Sperm Based on Stem Cell Competition

A challenge for the Quality Control of Sperm Based on Stem Cell Competition
基于干细胞竞争的精子质量控制挑战
批准号：
22657058
负责人：
YOSHIDA Shosei
金额：
$2.13万
依托单位：
National Institute for Basic Biology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22657058/
关键词：
精子形成遺伝情報幹細胞品質保証マウス

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中文摘要
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英文摘要
This study has investigated the competition between mouse spermatogenic stem cells that plays a crucial role in the quality control of sperm, by means of pulse label-chase of spermatogenic stem cells in combination with mathematical and statistical analyses. As a result, it has been discovered that stem cells are always turning over with each other and many of the stem cells lose their function while a small number of stem cell cohorts expand, which is contrary to a prevailing thought that stem cells are a few special cell types that always dived asymmetrically. Moreover, it has been discovered that stem cells' turnover occurs in a stochastic manner.
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Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment.
DOI： 10.1126/science.1182868
发表时间： 2010-04-02
期刊： Science (New York, N.Y.)
影响因子： --
作者： [Nakagawa T, Sharma M, Nabeshima Y, Braun RE, Yoshida S]
通讯作者： Yoshida S
The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.
DOI： 10.1016/j.devcel.2010.09.010
发表时间： 2010-10-19
期刊： DEVELOPMENTAL CELL
影响因子： 11.8
作者： [Matson, Clinton K., Murphy, Mark W., Griswold, Michael D., Yoshida, Shosei, Bardwell, Vivian J., Zarkower, David]
通讯作者： Zarkower, David
"Characterization of mouse male germline stem cell niche by gene expression profiling using laser capture microdissection"
“使用激光捕获显微切割通过基因表达谱表征小鼠雄性生殖干细胞生态位”
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Yu Kitadate, Ayumi Maruyama, Rie Ichikawa, Shosei Yoshida]
通讯作者： Shosei Yoshida
Stem cell niche system in mouse spermatogenesis. Stem Cell Biology and Regenerative Medicine Series,"Male Germline Stem Cells : Developmental and Regenerative Potential"
小鼠精子发生中的干细胞生态位系统。
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [A. Spradling, M. T. Fuller, R. E. Braun, and S. Yoshida, S. Yoshida]
通讯作者： S. Yoshida
共 42 条
    Comprehensive analysis of mouse germ line using genetic barcoding
    • 批准号：
      17K19413
    • 项目类别：
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额：
      $4.16万
    • 财政年份：
      2017
    • 负责人：
      YOSHIDA Shosei
    • 依托单位：
      National Institute for Basic Biology
    Germ cell selection and competition leading to spermatogenesis
    • 批准号：
      16H02507
    • 项目类别：
      Grant-in-Aid for Scientific Research (A)
    • 资助金额：
      $27.46万
    • 财政年份：
      2016
    • 负责人：
      YOSHIDA Shosei
    • 依托单位：
      National Institute for Basic Biology
    Analysis of potential stem cells that change their fate from differentiation to self-renewal and support the regeneration of spermatogenesis
    • 批准号：
      24247041
    • 项目类别：
      Grant-in-Aid for Scientific Research (A)
    • 资助金额：
      $29.37万
    • 财政年份：
      2012
    • 负责人：
      YOSHIDA Shosei
    • 依托单位：
      National Institute for Basic Biology
    Role of ngn3, a bHLH transcription factor, in the establishment and maintenance of the mouse spermatogenic stem cells
    • 批准号：
      17570177
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.24万
    • 财政年份：
      2005
    • 负责人：
      YOSHIDA Shosei
    • 依托单位：
      Kyoto University
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