Novel function of oxytocin : its anorectic neuronal pathway and(patho) physiological role in regulating feeding

催产素的新功能：其厌食神经元通路和调节摄食的（病理）生理作用

• 批准号: 22659044
• 负责人: YADA Toshihiko
• 金额: $ 1.98万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659044/
• 关键词: Oxytocin; Nesfatin-1; 摂食; 体重; 室傍核; オキシトシン; POMC; 視床下部

PVN Nesf neuron's downstream circuits and upstream regulators(1) Histological and physiological data supported that the Oxt neuron in the hypothalamic PVN projects to the POMC neuron in the ARC, in addition to the NTS POMC neuron in the NTS as previously reported.(2) Re-feeding following 48 hours fasting neither affected the mRNA levels for PVN Oxt and ARC POMC nor further increased the red fluorescence in the PVN of Oxt-mRFP-Tg rats.(3) PVN Nesf neurons that regulate oxytocin neurons were activated directly by high glucose and insulin, the meal-evoked factors.Peripheral administration of Oxt suppresses feeding and ameliorates obesity(1) Oxt increased cytosolic Ca^<2+> in Nodose Ganglion Neurons isolated from the vagal afferent of mice.(2) In high fat diet-induced obese mice, peripheral administration of Oxt ameliorated obesity, visceral fat accumulation, fatty liver and hyperglycemia, thereby showing ant-obesity and anti-metabolic syndrome effects.Involvement of PVN Nesf-Oxt system in stress responses(1) Restrain stress activated Nesf neurons in the stress-related nuclei.(2) Central injection of Nesf activated noradrenalin, serotonin and CRH neurons and increased plasma levels of ACTH and glucocorticoid, which are key mediators of stress responses

下丘脑室旁核神经元的下游回路和上游调节因子(1)组织学和生理学数据支持下丘脑PVN内的oxt神经元投射到ARC内的POMC神经元，以及先前报道的NTS中的POMC神经元。(2)禁食48小时后再喂食既不影响oxt-MRFP-TG大鼠PVN内OXT和ARC POMC的mRNA水平，也不进一步增加PVN内红色荧光。(3)调节催产素神经元的PVN内神经元直接被高糖和餐后诱发因子胰岛素激活。外周给药抑制和改善肥胖(1)oxt增加。(2)在高脂饮食诱导的肥胖小鼠中，外周注射OXT可以改善肥胖、内脏脂肪堆积、脂肪肝和高血糖，从而显示出抗肥胖和抗代谢综合征的作用。PVN-Nesf-oxt系统在应激反应中的作用：(1)抑制应激相关核团中被激活的Nesf神经元。(2)中央注射Nesf激活去甲肾上腺素、5-羟色胺和CRH神经元，并增加血浆ACTH和糖皮质激素的水平，这些是应激反应的关键介质

项目成果

視床下部室傍核Nesfatin-1はレプチン非依存性にOxytocin-POMC摂食抑制経路を作動する

下丘脑室旁核 Nesfatin-1 以不依赖瘦素的方式激活催产素-POMC 摄食抑制途径

• 发表时间: 2010
• 作者: Tahara Y;Hirao A;Moriya T;Kudo T;Shibata S.;矢田俊彦
• 通讯作者: 矢田俊彦

Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotropin releasing hormone pathway in the paraventricular nucleus of the hypothalamus.

长期输注脑源性神经营养因子可通过下丘脑室旁核中的促肾上腺皮质激素释放激素途径减少食物摄入量和体重。

• 发表时间: 2010
• 期刊: J Neuroendocrinol
• 影响因子: 3.2
• 作者: Toriya;M.
• 通讯作者: M.

日本薬理学雑誌

日本药理学杂志

• 发表时间: 2006
• 作者: 植田弘師;戸田一雄;Ueda H;植田弘師;植田弘師;植田弘師;植田弘師
• 通讯作者: 植田弘師

Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus.

• DOI: 10.18632/aging.100400
• 发表时间: 2011-11
• 期刊: Aging
• 作者: Maejima Y;Kohno D;Iwasaki Y;Yada T
• 通讯作者: Yada T

視床下部室傍核の新規摂食調節因子

下丘脑室旁核中的新型喂养调节因子

• 发表时间: 2011
• 作者: 那須輝顕;片野坂公明;水村和枝;出崎克也;前島裕子
• 通讯作者: 前島裕子