Effects of oxytocin during the neonatal period on the development of the neural basis of social behavior

为了检测催产素系统的时间或位置特异性抑制对社会行为的影响，我们在催产素启动子的控制下产生了表达人白喉毒素受体的转基因大鼠。我们对转基因的种系传播进行了筛选，建立了6个在催产素合成神经元中表达人白喉毒素受体的转基因大鼠。另一方面，为了检测新生期间催产素受体的激活对成年后社会行为的影响，我们在出生后的前5天给小鼠注射了催产素。与我们的预期相反，注射催产素的小鼠成年后的社交、情绪和抑郁相关行为与对照组小鼠没有显著差异。

To examine effects of time-or site-specific inhibition of oxytocin system upon social behaviors, we generated transgenic rats expressing human diphtheria toxin receptor under the control of the oxytocin promoter. We screened for germ-line transmission of the transgene and established six lines of transgenic rats expressing human diphtheria toxin receptor in oxytocin-synthesizing neurons.On the other hand, to examine effects of the activation of oxytocin receptor during the neonatal period upon social behaviors in adulthood, we injected mice with oxytocin over the first five postnatal days. Contrary to our expectations, social, emotional and depression-related behaviors in adulthood of oxytocin-injected mice were not significantly different from control mice.