Effects of activation of oxytocin receptor in neonatal brain on the development of mother-infant attachment.

新生儿大脑催产素受体激活对母婴依恋发展的影响。

• 批准号: 20790194
• 负责人: TAKAYANAGI Yuki
• 金额: $ 2.66万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790194/
• 关键词: オキシトシン; オキシトシン受容体; 愛着行動; 社会行動; 情動行動; 母子; 母性行動; バゾプレシン; 嗅球; トランスジェニックラット

Maternal separation induced the activation of oxytocin-producing neurons in the supraoptic nucleus of mouse pups. Injection of oxytocin receptor antagonist in the neonatal period modulated anxiety-related and social behaviors in adulthood. On the other hand, to examine effects of increased oxytocin release at parturition upon fetal brain, we investigated the behavior of mice delivered by Cesarean section. Mice delivered by Cesarean section and then injected with oxytocin exhibited increased anxiety-related behavior as compared to mice delivered naturally. These results suggest that the activation of oxytocin receptor in neonatal brain during mother-infant interaction or parturition affects emotional and social behaviors in adulthood.

母体分离诱导小鼠幼崽上核中产生催产素神经元的激活。在新生儿时期注射催产素受体拮抗剂，调节了与焦虑相关的和社会行为。另一方面，为了检查分娩时催产素释放增加对胎儿脑的影响，我们研究了剖宫产片段传递的小鼠的行为。与自然交付的小鼠相比，由剖宫产片并注射催产素的小鼠表现出与焦虑相关的行为的增加。这些结果表明，母亲相互作用或分娩过程中新生儿大脑中催产素受体的激活会影响成年后的情绪和社会行为。

项目成果

Oxytocin and appetite

• DOI: 10.1016/s0079-6123(08)00413-5
• 发表时间: 2008-01-01
• 期刊: ADVANCES IN VASOPRESSIN AND OXYTOCIN: FROM GENES TO BEHAVIOUR TO DISEASE
• 作者: Leng, Gareth;Onaka, Tatsushi;Takayanagi, Yuki
• 通讯作者: Takayanagi, Yuki

Oxytocin receptor-deficient mice developed late-onset obesity.

催产素受体缺陷的小鼠出现迟发性肥胖。

• 发表时间: 2008
• 期刊: Neuroreport 19(in press)
• 作者: Takayanagi;Y. ;et. al.
• 通讯作者: et. al.

Roles of PrRP and oxytocin receptor in stress-induced increase of energy expenditure.

PrRP 和催产素受体在应激诱导的能量消耗增加中的作用。

• 发表时间: 2010
• 作者: 鎌田恭輔;太田貴裕;川合謙介;斉藤延人;Takayanagi Y
• 通讯作者: Takayanagi Y

Role of prolactinreleasing peptide in stress-induced energy

催乳素释放肽在应激诱导能量中的作用

• 发表时间: 2009
• 作者: 西森克彦;吉田匡秀;笠原好之;高柳友紀;Takayanagi Y;Nishimori K;Leng G;Takayanagi Y;西森克彦;Onaka T;Takayanagi Y;Takayanagi Y;Kaewwongse M;Takayanagi Y
• 通讯作者: Takayanagi Y

Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice

• DOI: 10.1523/jneurosci.5593-08.2009
• 发表时间: 2009-02-18
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Yoshida, Masahide;Takayanagi, Yuki;Nishimori, Katsuhiko
• 通讯作者: Nishimori, Katsuhiko