The application of stable isotope breath test and biopterin administration to the evaluation and treatment of psychiatric disorders

苯丙氨酸是合成儿茶酚胺所必需的。本文应用C^^<13>-苯丙氨酸呼气试验（C^^<13>-PBT），测定<13>C^^ -苯丙氨酸代谢产生的总C^^ O_2<13>，以C^^<13>O_2/C^^<12>O_2的比值，对精神病患者进行了检测。研究对象为91名精神分裂症患者、77名抑郁症患者、32名双相情感障碍患者和181名正常对照。精神<13>分裂症患者的C^^ -PBT结果和血清BH 4水平显著低于对照组。在<13>具有低C^^ -PBT结果和血清BH 4水平的患者中进行BH 4给药后的C^^ -PBT<13>，但是C^^<13>-PBT结果没有改善。通过呼气试验测定苯丙氨酸代谢、BH_4水平与精神症状之间的关系，有助于阐明精神疾病的病理生理机制。

Phenylalanine is required for the synthesis of catecholamines. C^^<13>-labeled phenylalanine breath test(C^^<13>-PBT), in which total C^^<13> O_2 produced through metabolism of C^^<13>-phenylalanine was measured as C^^<13> O_2/C^^<12> O_2 ratio, was administered to psychiatric patients. The subjects were 91 schizophrenia, 77 depression, 32 bipolar disorder patients and 181 controls. C^^<13>-PBT results and serum BH4 level were significantly lower in the schizophrenia patients than in the controls. C^^<13>-PBT after administration of BH4 was conducted in patients who had had both low C^^<13>-PBT results and serum BH4 level, however C^^<13>-PBT results were not improved. Examination of relationship between phenylalanine metabolism measured by breath test, BH4 level, and psychiatric symptoms may attribute to elucidate the pathophysiology of mental disease.