The application of stable isotope breath test and biopterin administration to the evaluation and treatment of psychiatric disorders

苯丙氨酸是合成儿茶酚胺所必需的。对精神病患者进行C^&lt；13&gt；标记苯丙氨酸呼气试验(C^&lt；13&gt；-PBT；)，测定C^&lt；13&gt；-苯丙氨酸代谢产生的总C^&lt；13&gt；O_2/C^&t；O_2；12&gt；O_2比值。受试者包括91例精神分裂症、77例抑郁症、32例双相情感障碍患者和181例对照组。精神分裂症患者PBT结果和血清BH4水平均显著低于对照组。对于C^&lt；13；-PBT结果和血清BH4水平均较低的患者，给予BH4治疗后进行C^&lt；13&>-PBT，但C^&lt；13&>-PBT结果无改善。通过呼气试验检测苯丙氨酸代谢、BH4水平和精神症状之间的关系有助于阐明精神疾病的病理生理学。

Phenylalanine is required for the synthesis of catecholamines. C^^<13>-labeled phenylalanine breath test(C^^<13>-PBT), in which total C^^<13> O_2 produced through metabolism of C^^<13>-phenylalanine was measured as C^^<13> O_2/C^^<12> O_2 ratio, was administered to psychiatric patients. The subjects were 91 schizophrenia, 77 depression, 32 bipolar disorder patients and 181 controls. C^^<13>-PBT results and serum BH4 level were significantly lower in the schizophrenia patients than in the controls. C^^<13>-PBT after administration of BH4 was conducted in patients who had had both low C^^<13>-PBT results and serum BH4 level, however C^^<13>-PBT results were not improved. Examination of relationship between phenylalanine metabolism measured by breath test, BH4 level, and psychiatric symptoms may attribute to elucidate the pathophysiology of mental disease.