The application of stable isotope breath test and biopterin administration to the evaluation and treatment of psychiatric disorders

稳定同位素呼气试验和生物蝶呤给药在精神疾病评估和治疗中的应用

• 批准号: 22659215
• 负责人: KUNUGI Hiroshi
• 金额: $ 2.11万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659215/
• 关键词: 脳・神経; 脳神経疾患; 神経科学; 薬学; バイオテクノロジー

Phenylalanine is required for the synthesis of catecholamines. C^^<13>-labeled phenylalanine breath test(C^^<13>-PBT), in which total C^^<13> O_2 produced through metabolism of C^^<13>-phenylalanine was measured as C^^<13> O_2/C^^<12> O_2 ratio, was administered to psychiatric patients. The subjects were 91 schizophrenia, 77 depression, 32 bipolar disorder patients and 181 controls. C^^<13>-PBT results and serum BH4 level were significantly lower in the schizophrenia patients than in the controls. C^^<13>-PBT after administration of BH4 was conducted in patients who had had both low C^^<13>-PBT results and serum BH4 level, however C^^<13>-PBT results were not improved. Examination of relationship between phenylalanine metabolism measured by breath test, BH4 level, and psychiatric symptoms may attribute to elucidate the pathophysiology of mental disease.

苯丙氨酸是合成儿茶酚胺所必需的。采用C^^<13>-PBT呼气试验方法，测定了C^^<13>-苯丙氨酸代谢产生的总C^^<13> O_2/C^^<12> O_2的比值。研究对象包括91名精神分裂症患者、77名抑郁症患者、32名双相情感障碍患者和181名对照组。精神分裂症患者的C^^<13>-PBT结果和血清BH4水平明显低于对照组。对C^^<13>-PBT和血清BH4水平均较低的患者给予BH4后进行C^^<13>-PBT，但C^^<13>-PBT结果没有改善。通过呼吸试验检测苯丙氨酸代谢、BH4水平与精神症状之间的关系，可能有助于阐明精神疾病的病理生理学。

项目成果

13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients.

• DOI: 10.1038/tp.2012.48
• 发表时间: 2012-05-22
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Teraishi T;Ozeki Y;Hori H;Sasayama D;Chiba S;Yamamoto N;Tanaka H;Iijima Y;Matsuo J;Kawamoto Y;Kinoshita Y;Hattori K;Ota M;Kajiwara M;Terada S;Higuchi T;Kunugi H
• 通讯作者: Kunugi H