Profiling of microRNAs in mouse mandibular condylar cartilage during development

小鼠下颌髁软骨发育过程中 microRNA 的分析

• 批准号: 22659376
• 负责人: TAKAHASHI Ichiro
• 金额: $ 2.24万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659376/
• 关键词: microRNA; 下顎頭軟骨; 歯科矯正学; 軟骨細胞分化; 細胞・組織; 軟骨細胞; 下顎頭; 遺伝子発現制御

We focused on miR-200a by microarray analysis of developing mandibular condylar cartilage (MCC) in mouse. Transfection experiments of miR-200a inhibitor or mimic were performed and demonstrated that miR-200a contributes to chondrogenesis in developing MCC through the control of proliferation and differentiation in MCC cells

本研究通过微阵列技术分析小鼠下颌髁突软骨（MCC）发育过程中miR-200 a的表达。进行了miR-200 a抑制剂或模拟物的转染实验，并证明miR-200 a通过控制MCC细胞的增殖和分化而有助于发育中MCC的软骨形成

项目成果

Fabrication of Carbonate Apatite Block from Calcium Sulfate by Hydrothermal Treatment

水热处理硫酸钙制备碳酸盐磷灰石块体

• 发表时间: 2011
• 作者: 塚本亮一;北村尚正;赤澤友基;三留雅人;Nomura S
• 通讯作者: Nomura S

Fibroblast growth factor 10 regulates Meckel's cartilage formation during early mandibular morphogenesis in rats

成纤维细胞生长因子 10 在大鼠早期下颌形态发生过程中调节梅克尔软骨的形成

• 发表时间: 2011
• 期刊: Dev Biol
• 影响因子: 2.7
• 作者: Terao F;Takahashi I;Mitani H;Haruyama N;Sasano Y;Suzuki O;Takano-Yamamoto T
• 通讯作者: Takano-Yamamoto T

The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling

• DOI: 10.1016/j.bone.2010.11.014
• 发表时间: 2011-04-01
• 期刊: BONE
• 影响因子: 4.1
• 作者: Nagata, Masaki;Nuckolls, Glen H.;Slavkin, Harold C.
• 通讯作者: Slavkin, Harold C.

Mechano-Biology of cytoskeletal reorganization in differentiating chondrocytes.

分化软骨细胞中细胞骨架重组的力学生物学。

• 发表时间: 2010
• 作者: 笠原真琴;杉山千尋;野原幹司;古郷幹彦;田中晋;阪井丘芳;Takahashi I
• 通讯作者: Takahashi I

Three-dimensional analyisis of the temporomandibular joint and fossa-condyle relationship.

颞下颌关节及窝髁关系的三维分析。

• 发表时间: 2011
• 期刊: Orthodontics
• 作者: Endo M;Terajima M;Goto T;Tokumori K;Takahashi I
• 通讯作者: Takahashi I