The search for original protein and biokinetics of antihypertensive peptide derived from Jellyfish Stomolophus nomurai

野村水母降压肽的原始蛋白及其生物动力学研究

• 批准号: 22700735
• 负责人: MORINAGA Yae
• 金额: $ 2.25万
• 依托单位: Aomori University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700735/
• 关键词: 食素材; エチゼンクラゲ; ペプチド; 非コラーゲンタンパク質; コラーゲン; 降圧活性; タンパク質

I found the antihypertensive peptide YYAPFE derived from Jellyfish Stomolophus nomurai. The peptide has not a characteristic triple-helical conformation of collagen that is derived from the [Gly-X-Y]n sequence. Therefore, the original protein of the peptide was estimated to be non-collagen protein. Furthermore, I searched long chain peptide derived from non-collagen protein. A new nonadecapeptide was identified as NKPLAGSPAASELYTEAGG. However, the peptide has not ACE inhivitory activity.

我发现抗高血压肽YYAPFE来自水母Stomolophus nomurai。该肽不具有源自[Gly-X-Y]n序列的胶原蛋白的特征性三螺旋构象。因此，该肽的原始蛋白质被估计为非胶原蛋白。此外，我还搜索了来自非胶原蛋白的长链肽。一个新的十九肽被鉴定为NKPLAGSPAASELYTEAGG。然而，该肽不具有ACE抑制活性。

项目成果

A New ACE Inhibitory and Antihypertensive Peptide Derived from Jelly fish Stomolophus nomurai

一种源自水母 Stomolophus nomurai 的新型 ACE 抑制和降压肽

• 发表时间: 2011
• 作者: Yae Morinaga;Kunihisa Iwai;Hidehiro Tomita;Yoshiaki Takaya;Tetsushi Naraoka;Hajime Matsue
• 通讯作者: Hajime Matsue

Chemical Nature of a New Antihypertensive Peptide Derived from Jellyfish

• DOI: 10.3136/fstr.16.333
• 发表时间: 2010-07
• 期刊: Food Science and Technology Research
• 影响因子: 0.6
• 作者: Yae Morinaga;K. Iwai;H. Tomita;Y. Takaya;Tetsushi Naraoka;H. Matsue